Recent advances in nonviral vectors for gene delivery.

  title={Recent advances in nonviral vectors for gene delivery.},
  author={Xia Nan Guo and Leaf Huang},
  journal={Accounts of chemical research},
  volume={45 7},
Gene therapy has long been regarded a promising treatment for many diseases, whether acquired (such as AIDS or cancer) or inherited through a genetic disorder. A drug based on a nucleic acid, however, must be delivered to the interior of the target cell while surviving an array of biological defenses honed by evolution. Successful gene therapy is thus dependent on the development of an efficient delivery vector. Researchers have pursued two major vehicles for gene delivery: viral and nonviral… CONTINUE READING
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