Recent advances in myelodysplasia: update from 2011 ASH annual meeting

Abstract

Significant progresses have been made in genetic research in MDS. Through RNA interference technology, knockdown of RPS14 recapitulated the pathological process of decreased erythropoiesis [1]. Transgenic expression of RPS14 in 5qMDS cells rescued the phenotype of insufficient erythropoiesis. This strongly suggests that haploinsufficiency of RPS14 is one of… (More)

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