Recent advances in myelodysplasia: update from 2011 ASH annual meeting


Significant progresses have been made in genetic research in MDS. Through RNA interference technology, knockdown of RPS14 recapitulated the pathological process of decreased erythropoiesis [1]. Transgenic expression of RPS14 in 5qMDS cells rescued the phenotype of insufficient erythropoiesis. This strongly suggests that haploinsufficiency of RPS14 is one of… (More)


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