Recent advances in molecular genetics of breast cancer

  title={Recent advances in molecular genetics of breast cancer},
  author={Kre{\vs}imir Paveli{\'c} and Koraljka Gall-Tro{\vs}elj},
  journal={Journal of Molecular Medicine},
Breast cancer is among the most common tumors affecting women. It is characterized by a number of genetic aberrations. Some 5–10% of cases are thought to be inherited. The hereditary breast and ovarian cancer syndrome includes genetic alterations of various susceptibility genes, particularly BRCA1 and BRCA2. Breast tumors of patients with germ-line mutations in the BRCA1 and BRCA2 genes have more genetic defects than sporadic breast tumors. Here we review new findings in the function of BRCA1… CONTINUE READING


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