Recent advances in magnetofection and its potential to deliver siRNAs in vitro.

@article{Mykhaylyk2009RecentAI,
  title={Recent advances in magnetofection and its potential to deliver siRNAs in vitro.},
  author={Olga Mykhaylyk and Olivier Zelphati and Edelburga Hammerschmid and Martina Anton and Joseph Rosenecker and Christian Plank},
  journal={Methods in molecular biology},
  year={2009},
  volume={487},
  pages={111-46}
}
This chapter describes how to design and conduct experiments to deliver siRNA to adherent mammalian cells in vitro by magnetic force-assisted transfection using self-assembled complexes of small interfering RNA (siRNA) and cationic lipids or polymers that are associated with magnetic nanoparticles. These magnetic complexes are targeted to the cell surface by the application of a magnetic gradient field. In this chapter, first we describe the synthesis of magnetic nanoparticles for… CONTINUE READING

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