Recent advances in high-throughput quantitative bioanalysis by LC-MS/MS.

@article{Xu2007RecentAI,
  title={Recent advances in high-throughput quantitative bioanalysis by LC-MS/MS.},
  author={Raymond Naxing Xu and Leimin Fan and Matthew J. Rieser and Tawakol A. El-Shourbagy},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2007},
  volume={44 2},
  pages={
          342-55
        }
}
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471 Citations
Highly Influential Citations
10
Background Citations
66
Methods Citations
49

471 Citations

Bioanalytical hydrophilic interaction chromatography: recent challenges, solutions and applications.

Applications of HILIC-MS/MS are summarized, including those for pharmacokinetic studies, metabolic studies, therapeutic drug monitoring and clinical diagnostics, and advancements in the better understanding of retention characteristics of analytes with different mobile- and stationary-phase compositions.

High-performance liquid chromatography–tandem mass spectrometry in the identification and determination of phase I and phase II drug metabolites

Applications of tandem mass spectrometry (MS/MS) techniques coupled with high-performance liquid chromatography (HPLC) in the identification and determination of phase I and phase II drug metabolites…

Recent advances in application of hydrophilic interaction chromatography for quantitative bioanalysis.

Hydrophilic interaction chromatography (HILIC) provides a complementary separation mode to RPLC and thus has been gaining increased utilization in LC-MS/MS based quantitative bioanalysis and extended to quantitation of relatively non-polar compounds, peptides and biomarkers.

Quantification of polar drugs in human plasma with liquid chromatography-tandem mass spectrometry.

This review summarizes the recent progress on quantification of polar drugs in plasma with LC-MS/MS andStationary phases of mixed mode and porous graphitic carbon materials are gaining acceptance in bioanalytical applications.

Leveraging Advances in HPLC and Sample Preparation to Maximize DMPK Data Quality

High throughput bioanalytical methods are essential to support the rapid discovery and development of drugs in the pharmaceutical industry and effective sample preparation and appropriate chromatographic separation of endogenous matrix components is required to ensure the quality of the data.

Highly sensitive LC-MS-MS analysis of a pharmaceutical compound in human plasma using monolithic phase-based on-line extraction.

This work has developed a highly sensitive liquid chromatography-tandem mass spectrometry assay for quantitative determination of a pharmaceutical compound in human plasma that exhibited good tolerance to matrix effect and has been applied successfully to a clinical study.

Supercritical fluid chromatography‐tandem mass spectrometry for high throughput bioanalysis of small molecules in drug discovery

State-of-the-art in fast liquid chromatography-mass spectrometry for bio-analytical applications.

Systematic evaluation of matrix effects in supercritical fluid chromatography versus liquid chromatography coupled to mass spectrometry for biological samples.

Surface-activated chemical ionization-electrospray ionization mass spectrometry combined with two-dimensional serial chromatography is a powerful tool for drug stability studies.

This work introduces an innovative approach that incorporates two-dimensional liquid chromatography (2D-LC) in conjunction with an MS system consisting of a surface-activated chemical ionization-electrospray ionization chamber (SACI-ESI), an ion trap MS analyzer, and tandem mass spectrometry.
...

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