Recent advances in head and neck cancer.

@article{Haddad2008RecentAI,
  title={Recent advances in head and neck cancer.},
  author={Robert I Haddad and Dong M. Shin},
  journal={The New England journal of medicine},
  year={2008},
  volume={359 11},
  pages={
          1143-54
        }
}
  • R. Haddad, D. Shin
  • Published 11 September 2008
  • Medicine
  • The New England journal of medicine
There are more than half a million incident cases of squamous-cell carcinoma of the head and neck worldwide each year, primarily affecting the oropharynx, oral cavity, hypopharynx, and larynx. This review considers the biologic features of these tumors, including the role of human papillomavirus as a risk factor for cancer of the oropharynx. New therapies are considered, along with management approaches. 

Figures, Tables, and Topics from this paper

Comparative Study of Mucositis in Patients of Head and Neck Cancer Treated by External Radiotherapy with or Without Amifostine.
TLDR
In Kuwait, cancer of the head and neck region impairs many activities of daily life such as chewing, speaking and swallowing.
Current trends in oral cancer: A review
TLDR
This review summarizes the incidence, prevalence and mortality rates associated with oral cancer and investigated the strategies for early diagnosis, the molecular pathway of carcinogenesis, and the current treatment modalities available for oral cancer.
Predictive Markers of Treatment Resistance in Head and Neck Squamous Cell Carcinoma
TLDR
Head and neck cancer is a common malignancy with approximately 600 000 new cases yearly, and the overall survival has not increased over the last decades.
New trends in the management of head and neck cancers.
  • N. Matar, A. Haddad
  • Medicine
    Le Journal medical libanais. The Lebanese medical journal
  • 2011
TLDR
This review presents the state of the art of the management of head and neck cancer in 2011 with emphasis on the most recent advances in the assessment, treatment and follow-up.
The Molecular Pathology of Head and Neck Squamous Cell Carcinoma
TLDR
This chapter reviews the clinical and pathologic features of and the molecular pathways involved in tumorigenesis of conventional and HPV-associated HNSCC.
Histopathological features of clinical perineural invasion of cutaneous squamous cell carcinoma of the head and neck and the potential implications for treatment
Nonmelanoma skin cancer (NMSC) with perineural invasion (PNI) is most commonly seen in cutaneous squamous cell carcinoma of the head and neck (SCCHN). The cranial nerves are a conduit for skin cancer
Multidisciplinary Approach of Unresectable Head and Neck Cancer
The management of locally advanced head and neck cancer has seen the emergence of different combined modality therapies in recent years and new types of treatments, such as chemoradiation, new
Immunological Treatment Options for Locoregionally Advanced Head and Neck Squamous Cell Carcinoma
TLDR
The current status of the art and the future challenges in HNSCC treatment and prevention are reviewed and the potential of immunotherapy is discussed.
Oral and oropharyngeal cancer.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 102 REFERENCES
Head and neck cancer.
TLDR
There have been important advances in understanding of the molecular pathogenesis and progression of head and neck cancer and also in approaches to therapy, which include innovations in surgery, radiation therapy, and cytotoxic-drug therapy.
Head and Neck Cancer in CNonsmokers: A Distinct Clinical and Molecular Entity
TLDR
Clinical and molecular patterns of head and neck squamous cell carcinoma in nonsmokers and smokers may be different, and analysis of these patterns may improve understanding and management of this disease.
Tongue and tonsil carcinoma
TLDR
The objective of the current study was to explore the trends in both oral cavity and pharyngeal squamous cell carcinoma (SCC) in younger U.S. populations, in particular tongue and tonsillar SCC.
No Association between hOGG1 Ser326Cys polymorphism and risk of squamous cell carcinoma of the head and neck.
  • Zhengdong Zhang, Q. Shi, +5 authors Q. Wei
  • Medicine
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2004
TLDR
Tobacco smoke and alcohol use are the major risk factors for Squamous cell carcinoma of the head and neck.
Head and neck cancer: recent advances and new standards of care.
TLDR
This research highlights the need to understand more fully the role of otolaryngology in the development of central giant cell granuloma, as well as its role in the Kessler’s disease.
Phase II study of the antiangiogenesis agent thalidomide in recurrent or metastatic squamous cell carcinoma of the head and neck
TLDR
This Phase II study to determine the activity, toxicity profile, and antiangiogenic effect of thalidomide in patients with locoregionally recurrent or metastatic squamous cell carcinoma of the head and neck.
The p53 network in head and neck cancer.
Multiple oral squamous epithelial lesions: are they genetically related?
TLDR
The results suggest that the majority of MOCP arise from clonally independent cells affected by field cancerization, however, the probability of mucosal spread of clonal malignant or premalignant cells may increase along with malignant progression.
Defining risk levels in locally advanced head and neck cancers: A comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501)
In 2004, level I evidence was established for the postoperative adjuvant treatment of patients with selected high‐risk locally advanced head and neck cancers, with the publication of the results of
...
1
2
3
4
5
...