Recent advances in genetic predisposition to clinical acute lung injury.

@article{Gao2009RecentAI,
  title={Recent advances in genetic predisposition to clinical acute lung injury.},
  author={Li Gao and Kathleen Carole Barnes},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2009},
  volume={296 5},
  pages={L713-25}
}
It has been well established that acute lung injury (ALI), and the more severe presentation of acute respiratory distress syndrome (ARDS), constitute complex traits characterized by a multigenic and multifactorial etiology. Identification and validation of genetic variants contributing to disease susceptibility and severity has been hampered by the profound heterogeneity of the clinical phenotype and the role of environmental factors, which includes treatment, on outcome. The critical nature of… CONTINUE READING

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