Recent advances in gastrointestinal pathophysiology: role of heat shock proteins in mucosal defense and ulcer healing.

@article{Tsukimi2001RecentAI,
  title={Recent advances in gastrointestinal pathophysiology: role of heat shock proteins in mucosal defense and ulcer healing.},
  author={Yasuhiro Tsukimi and Sachiko Okabe},
  journal={Biological & pharmaceutical bulletin},
  year={2001},
  volume={24 1},
  pages={1-9}
}
The defense mechanism of the gastrointestinal mucosa against aggressive factors, such as hydrochloric acid, bile acid and non-steroidal anti-inflammatory drugs, mainly consists of functional, humoral and neuronal factors. Mucus-alkaline secretion, mucosal microcirculation, and motility act as functional factors, while prostaglandins and nitric oxide act as humoral factors, and capsaicin sensitive sensory neurons act as neuronal factors. All the above factors are known to contribute to mucosal… CONTINUE READING

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