Recent advances in freeze-fracture electron microscopy: the replica immunolabeling technique

@article{Robenek2008RecentAI,
  title={Recent advances in freeze-fracture electron microscopy: the replica immunolabeling technique},
  author={Horst Robenek and Nicholas J. Severs},
  journal={Biological Procedures Online},
  year={2008},
  volume={10},
  pages={9 - 19}
}
Freeze-fracture electron microscopy is a technique for examining the ultrastructure of rapidly frozen biological samples by transmission electron microscopy. Of a range of approaches to freeze-fracture cytochemistry that have been developed and tried the most successful is the technique termed freeze-fracture replica immunogold labeling (FRIL). In this technique samples are frozen fractured and replicated with platinum-carbon as in standard freeze fracture and then carefully treated with sodium… CONTINUE READING

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