Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver.

@article{You2004RecentAI,
  title={Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver.},
  author={M. X. You and David W Crabb},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2004},
  volume={287 1},
  pages={G1-6}
}
Alcohol has long been thought to cause fatty liver by way of altered NADH/NAD(+) redox potential in the liver, which, in turn, inhibits fatty acid oxidation and the activity of tricarboxylic acid cycle reactions. More recent studies indicate that additional effects of ethanol both impair fat oxidation and stimulate lipogenesis. Ethanol interferes with DNA binding and transcription-activating properties of peroxisome proliferator-activated receptor-alpha (PPARalpha), as demonstrated with… CONTINUE READING