Recent advances in a 1-adrenoceptor pharmacology

  title={Recent advances in a 1-adrenoceptor pharmacology},
  author={Taka-Aki Koshimizu and Akito Tanoue and Akira Hirasawa and Junji Yamauchi and G. Schwarz. M. Tsujimoto},
Abstract α 1 -Adrenergic receptors (ARs) mediate some of the main actions of the natural catecholamines, adrenaline and noradrenaline. They participate in many essential physiological processes, such as sympathetic neurotransmission, modulation of hepatic metabolism, control of vascular tone, cardiac contraction, and the regulation of smooth muscle activity in the genitourinary system. Here, we review recent progress on subtype-specific subcellular localization, participation in signaling… CONTINUE READING

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