Recent advances in SPE-chiral-HPLC methods for enantiomeric separation of chiral drugs in biological samples.

@article{Ali2013RecentAI,
  title={Recent advances in SPE-chiral-HPLC methods for enantiomeric separation of chiral drugs in biological samples.},
  author={Imran Ali and Syed Dilshad Alam and Zeid Abdullah Mohammad Al-Othman and Javed Abrar Farooqi},
  journal={Journal of chromatographic science},
  year={2013},
  volume={51 7},
  pages={
          645-54
        }
}
In medical practices, the determination of enantiomeric ratio of the chiral drugs is very important for their activities, bioavailabilities and biodegradation. Only homochiral medication is safe for humans. The chiral analysis in biological samples is the first and most important step. The present article describes the technical strategies of the enantiomeric resolution of racemic drugs in biological samples. Attempts have been made to describe sample preparation by solid-phase extraction and… CONTINUE READING

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