Recent advances in Ca(2+)-dependent Ras regulation and cell proliferation.

  title={Recent advances in Ca(2+)-dependent Ras regulation and cell proliferation.},
  author={Simon J Cook and Peter J. Lockyer},
  journal={Cell calcium},
  volume={39 2},
Our understanding of the mechanisms whereby growth factors stimulate cell proliferation through the Ras pathway stems largely from studies of the canonical pathway involving recruitment of Ras activators and inhibitors to the vicinity of receptor tyrosine kinases via phosphotyrosine-binding adaptor proteins. Ca(2+) has seldom joined the party, despite the identification of phospholipase Cgamma and Ca(2+) entry as receptor tyrosine kinase-dependent signals. Mechanisms by which Ca(2+) can… CONTINUE READING

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