Recent advancement in application of hydrophobic interaction chromatography for aggregate removal in industrial purification process.

@article{Lu2009RecentAI,
  title={Recent advancement in application of hydrophobic interaction chromatography for aggregate removal in industrial purification process.},
  author={Yuefeng Lu and Brian Williamson and Ronald Gillespie},
  journal={Current pharmaceutical biotechnology},
  year={2009},
  volume={10 4},
  pages={427-33}
}
Hydrophobic interaction chromatography (HIC) is a classic purification tool applied in protein and antibody, laboratory and industrial production process. It has been mainly used for the removal of both product-related impurities such as aggregates, as well as process contaminants such as host cell proteins. This review will focus on the recent development of HIC in its applications in the industrial purification processes. The process economy and requirements of high product purity and quality… CONTINUE READING

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