Recent advance in aminopeptidase N (APN/CD13) inhibitor research.

  title={Recent advance in aminopeptidase N (APN/CD13) inhibitor research.},
  author={Xin Zhang and Hao Fang and Jie Zhang and Yao-zong Yuan and Wenfang Xu},
  journal={Current medicinal chemistry},
  volume={18 32},
APN is an important zinc dependent metallo-exopeptidase, which can degrade the extracellular matrix, and plays an important role in tumor invasion, metastasis and angiogenesis. it has been considered as a suitable target for anti-cancer drug design. Recently, research of structure-based APN inhibitors is becoming an interesting field, and many APN inhibitors have been reported. Here we review a series of APN inhibitors and the recent progress in this field.