Recent achievements in Tc-99m radiopharmaceutical direct production by medical cyclotrons

  title={Recent achievements in Tc-99m radiopharmaceutical direct production by medical cyclotrons},
  author={A. Boschi and P. Martini and M. Pasquali and L. Uccelli},
  journal={Drug Development and Industrial Pharmacy},
  pages={1402 - 1412}
Abstract 99mTc is the most commonly used radionuclide in the field of diagnostic imaging, a noninvasive method intended to diagnose a disease, assess the disease state and monitor the effects of treatments. Annually, the use of 99mTc, covers about 85% of nuclear medicine applications. This isotope releases gamma rays at about the same wavelength as conventional X-ray diagnostic equipment, and owing to its short half-life (t½ = 6 h) is ideal for diagnostic nuclear imaging. A patient can be… Expand
Internal radiation dose assessment of radiopharmaceuticals prepared with cyclotron‐produced 99mTc
The aim of this work was to estimate the dose increase (DI) due to the contribution of Tc radioisotopes generated as impurities, after the intravenous injection of four radiopharmaceuticals prepared with cyclotron-produced 99m TC (CP-99m Tc) using 99.05% 100 Mo-enriched metallic targets. Expand
Environmental Radiation Doses from Patients Undergoing Tc-99m DMSA Cortical Renal Scintigraphy
The main objective of this study was to determine the environmental radiation doses in patients undergoing Tc-99m DMSA cortical renal scintigraphy, and the results are important in terms of knowing the radiation dose to which the patient will be exposed. Expand
Innovative Target for Production of Technetium-99m by Biomedical Cyclotron
A novel solid target preparation method was developed, including sputter deposition of a dense, adherent, and non-oxidized Mo target material onto a complex backing plate, which proved the chemical stability of the proposed backing materials was proven by gamma-spectroscopy analysis of the solution obtained after the standard dissolution procedure of irradiated targets in H2O2. Expand
The Radiopharmaceutical Chemistry of Technetium-99m
Technetium-99m (99mTc) is a radiometal that has nearly ideal nuclear properties for diagnostic nuclear medicine imaging, which has helped make it high impact and extensively utilized radionuclide inExpand
In-house cyclotron production of high-purity Tc-99m and Tc-99m radiopharmaceuticals.
  • P. Martini, A. Boschi, +17 authors A. Duatti
  • Environmental Science, Medicine
  • Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
  • 2018
It is conjectured that this alternative production route will not replace the current supply chain based on the distribution of 99Mo/99mTc generators, but could become a convenient emergency source of Tc-99m only for in-house hospitals equipped with a conventional, low-energy, medical cyclotron. Expand
14 MeV Neutrons for 99Mo/99mTc Production: Experiments, Simulations and Perspectives
This study highlights that a robust and viable solution, alternative to nuclear fission reactors, can be accomplished to secure the long-term supply of 99Mo and shows that this source, featuring a nominal neutron emission rate of about 1015 s−1, may potentially supply an appreciable fraction of the current 99Mo global demand. Expand
Nucleus Technetium-99 m Radiopharmaceuticals : A Review on Basic and Applied Aspects
Technetium-99m (Tc) usage is increasing worldwide at a rate of 32% per annum. Enriched Uranium235 is irradiated at nuclear reactor and subsequent process produces Molybdenum-99 (Mo) which decays toExpand
LARAMED: A Laboratory for Radioisotopes of Medical Interest
The LARAMED project was established a few years ago at LNL-INFN as a new research line aimed at exploiting the scientific power of nuclear physics for developing innovative applications to medicine, and is to elect LNL as a worldwide recognized hub for the development of production methods of novel medical radionuclides, still unavailable for the scientific and clinical community. Expand
Novel approaches to produce radionuclides using hot atom chemistry principles
Radionuclides are often used in the field of nuclear medicine. For some deceases the use of radionuclides is the best possible care, or even the only means of diagnosis or treatment. For theseExpand
Technetium-99m metastable radiochemistry for pharmaceutical applications: old chemistry for new products
Abstract Radiopharmacy is a pharmaceutical specialty responsible for the development and production of radiopharmaceuticals. Radiopharmaceuticals are radioactive drugs, which can be used in twoExpand


Evolution of Tc-99m in diagnostic radiopharmaceuticals.
The evolution of 99mTc dating back to its discovery, the development of 99Mo/99m Tc generators, and the efforts to exploit the diverse chemistry of the element to explore a spectrum of compounds for diagnostic imaging, planar, and single photon emission computed tomography are reviewed. Expand
Direct Technetium radiopharmaceuticals production using a 30MeV Cyclotron
The developed high power Mo target if constructed using enriched 100Mo, could be a practical method for large-scale production of 99mTc and promising as an alternative to fission product 99Mo-99MTc generators for local applications near cyclotron facilities. Expand
Radioisotopic Purity of Sodium Pertechnetate 99mTc Produced with a Medium-Energy Cyclotron: Implications for Internal Radiation Dose, Image Quality, and Release Specifications
Investigation of the radioisotopic purity of 99mTc produced at medium energy (20–24 MeV) and its impact on image quality and dosimetry is required to contribute to establishing a regulatory framework for using cyclotron-produced 99m Tc in routine clinical practice. Expand
188W/188Re Generator System and Its Therapeutic Applications
The 188Re radioisotope represents a useful radioisotope for the preparation of radiopharmaceuticals for therapeutic applications, particularly because of its favorable nuclear properties. The nuclideExpand
Clinical Trial with Sodium 99mTc-Pertechnetate Produced by a Medium-Energy Cyclotron: Biodistribution and Safety Assessment in Patients with Abnormal Thyroid Function
The systemic distribution, clinical safety, and imaging efficacy of cyclotron-produced 99mTc-NaTcO4 in humans provide supporting evidence for the use of this tracer as an equivalent for generator-eluted 99m Tc- NaTc O4 in routine clinical practice. Expand
Theoretical dosimetry estimations for radioisotopes produced by proton-induced reactions on natural and enriched molybdenum targets.
This study presents a summary of the dosimetry calculations performed for three technetium agents most commonly used in nuclear medicine diagnostic studies, namely sestamibi™, phosphonates and pertechnetate, labeled with cyclotron-produced technetanium, based on theoretical calculations of the proton-induced reaction cross sections and radioisotope production yields. Expand
Sustained Availability of 99mTc: Possible Paths Forward
The breadth of technologies and new strategies under development to provide 99Mo and 99mTc reflects both the broad interest in and the importance of the pivotal role of 99MTc in diagnostic nuclear medicine. Expand
Nuclear data for medical radionuclides
  • S. Qaim
  • Chemistry
  • Journal of Radioanalytical and Nuclear Chemistry
  • 2015
Radionuclides are used in medicine both for diagnosis and therapy. The radioactive decay data play a key role in the choice of a radionuclide for a certain application. The nuclear reaction data, onExpand
Molybdenum target specifications for cyclotron production of 99mTc based on patient dose estimates.
A simple and easy algorithm for dose estimation, based solely on the knowledge of target composition and beam energy, is described and a technique to determine Mo target composition thresholds that would meet any given dosimetry requirement is proposed. Expand
Implementation of Multi-Curie Production of 99mTc by Conventional Medical Cyclotrons
The direct production of 99mTc via proton bombardment of 100Mo can be practically achieved in high yields using conventional medical cyclotrons, which eliminates the need for enriched uranium and the radioactive waste associated with the processing of uranium targets. Expand