Recent Regulatory Changes Shaped Human Facial and Vocal Anatomy

  title={Recent Regulatory Changes Shaped Human Facial and Vocal Anatomy},
  author={David Gokhman and Lily Agranat-Tamir and Genevieve Housman and M. Nissim-Rafinia and Mar{\'i}a A. Nieves-Col{\'o}n and H. Gu and M. Ferrando and Pere Gelabert and I. Lipende and Ellen E. Quillen and A. Meissner and A. Stone and A. Pusey and D. Mjungu and L. Kandel and M. Liebergall and M. Prada and J. Vidal and J. Krause and B. Yakir and S. P{\"a}{\"a}bo and D. Reich and C. Lalueza-Fox and Tom{\`a}s Marqu{\`e}s-Bonet and E. Meshorer and L. Carmel},
  • David Gokhman, Lily Agranat-Tamir, +23 authors L. Carmel
  • Published 2017
  • Biology
  • bioRxiv
  • Identifying changes in gene regulation that shaped human-specific traits is critical to understanding human adaptation. Here, we use dozens of ancient and present-day DNA methylation maps to detect regulatory changes that emerged in modern humans. We show that genes affecting vocalization and facial features went through particularly extensive changes in methylation. Especially, we identify expansive changes in a network of genes regulating skeletal development (SOX9, ACAN and COL2A1), and in… CONTINUE READING
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