Recent Progress in Osteoarthritis and Rheumatoid Arthritis Research

  title={Recent Progress in Osteoarthritis and Rheumatoid Arthritis Research},
  author={Garl Kozlosky and Jacques J. Peschon},
  journal={Inflammation Research},
ROLE OF MEMBRANE-TYPE 1 MATRIX METALLOPROTEIN ASE IN CARTILAGE DESTRUCTION Yasunori Okada Department of Molecular Immunology and Pathology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan We examined biochemical characters of MTI-MMP and its expression in human osteoarthritic (OA) cartilage. Purified MTl-MMP could activate proMMP-2 and also degrade aggrecan, collagen types I, II, III, gelatin, fibronectin, vitronectin and laminin. MTl-MMP was immunolocalized to the chondrocytes… CONTINUE READING