Recent Progress in Histone Demethylase Inhibitors.

  title={Recent Progress in Histone Demethylase Inhibitors.},
  author={Tom E McAllister and Katherine S. England and Richard J Hopkinson and Paul E Brennan and Akane Kawamura and Christopher J. Schofield},
  journal={Journal of medicinal chemistry},
  volume={59 4},
There is increasing interest in targeting histone N-methyl-lysine demethylases (KDMs) with small molecules both for the generation of probes for target exploration and for therapeutic purposes. Here we update on previous reviews on the inhibition of the lysine-specific demethylases (LSDs or KDM1s) and JmjC families of N-methyl-lysine demethylases (JmjC KDMs, KDM2-7), focusing on the academic and patent literature from 2014 to date. We also highlight recent biochemical, biological, and… CONTINUE READING
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