Recent Development of Non-Peptide GnRH Antagonists

@article{Tukun2017RecentDO,
  title={Recent Development of Non-Peptide GnRH Antagonists},
  author={Feng-Ling Tukun and Dag Erlend Olberg and Patrick Johannes Riss and Ira H. Haraldsen and Anita Kaass and Jo Klaveness},
  journal={Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry},
  year={2017},
  volume={22}
}
The decapeptide gonadotropin-releasing hormone, also referred to as luteinizing hormone-releasing hormone with the sequence (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) plays an important role in regulating the reproductive system. It stimulates differential release of the gonadotropins FSH and LH from pituitary tissue. To date, treatment of hormone-dependent diseases targeting the GnRH receptor, including peptide GnRH agonist and antagonists are now available on the market. The inherited… 

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