Recent Development in Studies of Tetrahydroprotoberberines: Mechanism in Antinociception and Drug Addiction

@article{Chu2007RecentDI,
  title={Recent Development in Studies of Tetrahydroprotoberberines: Mechanism in Antinociception and Drug Addiction},
  author={Hong-Yuan Chu and Guozhang Jin and Eitan Friedman and Xuechu Zhen},
  journal={Cellular and Molecular Neurobiology},
  year={2007},
  volume={28},
  pages={491-499}
}
The tetrahydroprotoberberines (THPBs) are compounds isolated from Chinese herbs that possess a unique pharmacological profile as D2 dopamine receptor antagonists and D1 receptor agonists. l-Tetrahydropalmatine (l-THP) and l-stepholidine (SPD), members of the THPB family, were shown to have potential clinical use in the treatment of pain. However, their mechanism of action is not clear. In the past decades, Chinese scientists have made a great deal of effort to explore the mechanisms by which… 
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