Paragangliomas and pheochromocytomas are rare neuroendocrine tumors , which secrete catecholamines , with the same embryological origin from the neural crest cells .
Recent Advances in the Genetics of Pheochromocytomas and Paragangliomas .
Pheochromocytomas develop from the adrenal medulla , while paragangliomas are extraadrenal tumors , evolving from the autonomic sympathetic and parasympathetic nervous chains .
In addition to this , developments in molecular pathology of pheochromocytomas and paragangliomas will provide the key to target specifi c cellular markers , assuring a personalised therapy .
In this article we have reviewed the current medical literature , in order to summarise the most important aspects of genetics and clinical features of pheochromocytomas and paragangliomas .