Recent Advances in Understanding Aminoglycoside Ototoxicity and Its Prevention

  title={Recent Advances in Understanding Aminoglycoside Ototoxicity and Its Prevention},
  author={Weijing Wu and Su-Hua Sha and J. Schacht},
  journal={Audiology and Neurotology},
  pages={171 - 174}
  • Weijing Wu, Su-Hua Sha, J. Schacht
  • Published 2002
  • Medicine
  • Audiology and Neurotology
  • Studies over the last decade have left little doubt that reactive oxygen species (ROS) participate in the cellular events leading to aminoglycoside-induced hearing loss. The evidence ranges from the demonstration of aminoglycoside-mediated ROS formation in vitro to the prevention of ototoxicity by antioxidants in guinea pig in vivo. Here we review a hypothesis of the mechanism of toxicity, discuss possible causes underlying the gradient in base-to-apex sensitivity of outer hair cells, and… CONTINUE READING
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