Recent Advances in Targeting CD8 T-Cell Immunity for More Effective Cancer Immunotherapy

@inproceedings{Durgeau2018RecentAI,
  title={Recent Advances in Targeting CD8 T-Cell Immunity for More Effective Cancer Immunotherapy},
  author={Aur{\'e}lie Durgeau and Yasemin Virk and St{\'e}phanie Corgnac and Fathia Mami-Chouaib},
  booktitle={Front. Immunol.},
  year={2018}
}
Recent advances in cancer treatment have emerged from new immunotherapies targeting T-cell inhibitory receptors, including cytotoxic T-lymphocyte associated antigen (CTLA)-4 and programmed cell death (PD)-1. In this context, anti-CTLA-4 and anti-PD-1 monoclonal antibodies have demonstrated survival benefits in numerous cancers, including melanoma and non-small-cell lung carcinoma. PD-1-expressing CD8+ T lymphocytes appear to play a major role in the response to these immune checkpoint… CONTINUE READING

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