Recent Advances in Acne Pathogenesis: Implications for Therapy

@article{Das2014RecentAI,
  title={Recent Advances in Acne Pathogenesis: Implications for Therapy},
  author={Shinjita Das and Rachel V. Reynolds},
  journal={American Journal of Clinical Dermatology},
  year={2014},
  volume={15},
  pages={479-488}
}
Acne pathogenesis is a multifactorial process that occurs at the level of the pilosebaceous unit. While acne was previously perceived as an infectious disease, recent data have clarified it as an inflammatory process in which Propionibacterium acnes and innate immunity play critical roles in propagating abnormal hyperkeratinization and inflammation. Alterations in sebum composition, and increased sensitivity to androgens, also play roles in the inflammatory process. A stepwise approach to acne… 

Novel approaches in treatment of Acne vulgaris: Patents related to micro/nanoparticulated carrier systems

Novel drug delivery systems are promising option for improved acne treatment outcome, as they can diminish the side effects caused by the therapeutic agents or can modulate their properties and at the same time offering possibilities for modified release and improved skin penetration of the active substances.

Preliminary evaluation of the clinical efficacy of antihistamines as an adjuvant treatment to isotretinoin for acne vulgaris

Acne patients may experience better efficacy and clinical cure from the adjuvant use of H1-antagonists in combination with systemic isotrertinoin, although the occurrence of cutaneous side effects of isotretinoin is not affected by such combination.

BPX-01 Minocycline Topical Gel Shows Promise for the Treatment of Moderate-to-severe Inflammatory Acne Vulgaris.

Outcomes of two randomized, vehicle-controlled trials demonstrate effectiveness of BPX-01 topical minocycline gel in reducing P. acnes colonization and overall improvement in facial acne according to IGA, suggesting that the BPx-01 2% formulation is a promising treatment for moderate-to-severe nonnodular, inflammatory acne vulgaris.

Acne vulgaris

New treatment options with a shift towards targeting the early processes involved in acne development instead of suppressing the effects of end products will enhance the ability to improve the outcomes for patients with acne.

ACNE VULGARIS, RECENT UPDATES ON PATHOPHYSIOLOGY, DIAGNOSIS AND TREATMENT-A SYSTEMIC REVIEW STUDY

This study shows that the recent updates on the diagnosis and new treatments related to acne vulgaris is effective and it is a good step toward the new treatment modalities in the authors' dermatology specialty.

Oral Antibacterial Therapy for Acne Vulgaris: An Evidence-Based Review

There is insufficient evidence to support one type, dose, or duration of oral antibiotic over another in terms of efficacy; however, due to increasing resistance to antibiotics, dermatologists should heed consensus guidelines for their appropriate use.

Acne: relação hospedeiro-patogeno

The therapeutic targets are focused on the main factors involved in the etiopathogenesis of acne: the increase production of tallow, hyperkeratinization, colonization by P. acnes and inflammatory reaction produced, which includes resolution of the lesions, prevention of scars and reduction of psychological morbidity.

The relevance of sebum composition in the etiopathogeny of acne

The aim of this study was to review the literature regarding the new concepts on the pathogenesis of acne to find out whether modifications in the sebum composition lead to a greater proliferation and differentiation of keratinocytes that obstruct the follicular ostium and favor the formation of comedones.

Treatment of Acne Vulgaris by Topical Spironolactone Solution Compared With Clindamycin Solution

Spironolactone solution is an effective and well-tolerated topical treatment for mild to moderate acne vulgaris and is superior to clindamycin solution.

The Impact of Pyschological Stress on Acne.

The basis for the association between emotional stress and the onset or exacerbation of acne is in several cutaneous neurogenic factors which interact with a pathogenic cascade in acne.
...

References

SHOWING 1-10 OF 104 REFERENCES

Propionibacterium acnes: an update on its role in the pathogenesis of acne

Novel therapies should target molecules implicated in the activation of innate immunity, including toll‐like receptors, protease‐activated receptors and topical antimicrobial peptides; the latter may be an alternative to topical antibiotics and thus a solution for limiting bacterial resistance induced by topical macrolides.

Update in retinoid therapy of acne

Topical retinoids have been shown to expulse mature comedones, reduce microcomedone formation, and exert immunomodulatory effects, which justifies their use as first‐line treatment in most types of noninflammatory and inflammatory acne and makes them uniquely suitable as long‐term medication to maintain remission after cessation of initial combination therapy.

The role of toll-like receptors in the pathophysiology of acne.

New antibiotic therapies for acne and rosacea

The latest studies suggest anti‐inflammatory actions to be the most likely mechanism of antibiotics in acne and rosacea, shifting the focus to subantimicrobial‐dose oral antibiotics and/or topical antibiotic regimens as the preferred first‐line agents.

Toll-like receptor 2 activation and comedogenesis: implications for the pathogenesis of acne

TLR activation and secretion of IL-1α from keratinocytes may be initiating steps in comedogenesis and, therefore, critical to the pathophysiology of acne.

The development of antimicrobial resistance due to the antibiotic treatment of acne vulgaris: a review.

These findings suggest that antibiotics should be prescribed in combination with benzoyl peroxide and/or topical retinoids and be limited to a maximum of several months.

Contraceptive use in acne.

...