Recent Advances in Acne Pathogenesis: Implications for Therapy

  title={Recent Advances in Acne Pathogenesis: Implications for Therapy},
  author={Shinjita Das and Rachel V. Reynolds},
  journal={American Journal of Clinical Dermatology},
Acne pathogenesis is a multifactorial process that occurs at the level of the pilosebaceous unit. While acne was previously perceived as an infectious disease, recent data have clarified it as an inflammatory process in which Propionibacterium acnes and innate immunity play critical roles in propagating abnormal hyperkeratinization and inflammation. Alterations in sebum composition, and increased sensitivity to androgens, also play roles in the inflammatory process. A stepwise approach to acne… 

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