Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors

@inproceedings{GonzalezCordero2017RecapitulationOH,
  title={Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors},
  author={Anai Gonzalez-Cordero and Kamil Kruczek and Arifa Naeem and Milan Fernando and Magdalena Kloc and Joana Ribeiro and Debbie Goh and Yana{\'i} Dur{\'a}n and Samuel J. I. Blackford and Laura Abelleira-Hervas and Robert D. Sampson and Ian O. Shum and Matthew James Branch and Peter J. Gardner and Jane C. Sowden and James W B Bainbridge and Alexander D. Smith and Emma L. West and R. M. Akers R. E. Pearson and Robin R Ali},
  booktitle={Stem cell reports},
  year={2017}
}
Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited blindness. However, humans depend more upon cone photoreceptors that are required for daylight, color, and high-acuity vision. Indeed, macular retinopathies involving loss of cones are leading causes of blindness. An essential step for developing stem cell-based therapies for maculopathies is the ability to generate… CONTINUE READING
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