Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors

  title={Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors},
  author={Anai Gonzalez-Cordero and Kamil Kruczek and Arifa Naeem and Milan Fernando and Magdalena Kloc and Joana Ribeiro and Debbie Goh and Yana{\'i} Dur{\'a}n and Samuel J. I. Blackford and Laura Abelleira-Hervas and Robert D. Sampson and Ian O. Shum and Matthew James Branch and Peter J. Gardner and Jane C. Sowden and James W B Bainbridge and Alexander D. Smith and Emma L. West and R. M. Akers R. E. Pearson and Robin R Ali},
  booktitle={Stem cell reports},
Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited blindness. However, humans depend more upon cone photoreceptors that are required for daylight, color, and high-acuity vision. Indeed, macular retinopathies involving loss of cones are leading causes of blindness. An essential step for developing stem cell-based therapies for maculopathies is the ability to generate… CONTINUE READING
Highly Cited
This paper has 75 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 20 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 14 extracted citations

76 Citations

Citations per Year
Semantic Scholar estimates that this publication has 76 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 50 references

Cone Genesis Tracing by the Chrnb4-EGFP Mouse Line: Evidences of Cellular Material Fusion after Cone Precursor Transplantation

Molecular therapy : the journal of the American Society of Gene Therapy • 2017
View 5 Excerpts
Highly Influenced

Modeling early retinal development with human embryonic and induced pluripotent stem cells.

Proceedings of the National Academy of Sciences of the United States of America • 2009
View 1 Excerpt
Highly Influenced

Similar Papers

Loading similar papers…