Recapitulation and reversal of a persistent depression-like syndrome in rodents.

@article{Gourley2009RecapitulationAR,
  title={Recapitulation and reversal of a persistent depression-like syndrome in rodents.},
  author={Shannon L Gourley and Jane R. Taylor},
  journal={Current protocols in neuroscience},
  year={2009},
  volume={Chapter 9},
  pages={
          Unit 9.32
        }
}
Alterations in multiple biological functions, such as transcription factor activity, are implicated in the neurobiology of depression, based primarily on the characterization of antidepressant efficacy in naïve rodents rather than on models that capture the protracted feelings of anhedonia and helplessness that typify depression. This unit presents rat and mouse models of depression that involve chronic oral exposure to the stress-associated adrenal hormone, corticosterone (CORT), resulting in… CONTINUE READING
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