Recapitulating physiological and pathological shear stress and oxygen to model vasculature in health and disease

@inproceedings{Abaci2014RecapitulatingPA,
  title={Recapitulating physiological and pathological shear stress and oxygen to model vasculature in health and disease},
  author={Hasan Erbil Abaci and Yu-I Shen and Scott Tan and Sharon Gerecht},
  booktitle={Scientific reports},
  year={2014}
}
Studying human vascular disease in conventional cell cultures and in animal models does not effectively mimic the complex vascular microenvironment and may not accurately predict vascular responses in humans. We utilized a microfluidic device to recapitulate both shear stress and O2 levels in health and disease, establishing a microfluidic vascular model (μVM). Maintaining human endothelial cells (ECs) in healthy-mimicking conditions resulted in conversion to a physiological phenotype namely… CONTINUE READING
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