Recapitulating endochondral ossification: a promising route to in vivo bone regeneration.

  title={Recapitulating endochondral ossification: a promising route to in vivo bone regeneration.},
  author={Emmet M Thompson and Amos Matsiko and Eric Farrell and Daniel J. Kelly and Fergal J O'Brien},
  journal={Journal of tissue engineering and regenerative medicine},
  volume={9 8},
Despite its natural healing potential, bone is unable to regenerate sufficient tissue within critical-sized defects, resulting in a non-union of bone ends. As a consequence, interventions are required to replace missing, damaged or diseased bone. Bone grafts have been widely employed for the repair of such critical-sized defects. However, the well-documented drawbacks associated with autografts, allografts and xenografts have motivated the development of alternative treatment options… CONTINUE READING
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