Recall features and allorecognition in innate immunity

  title={Recall features and allorecognition in innate immunity},
  author={Hirofumi Uehara and Koichiro Minami and Markus Quante and Ye-qi Nian and Timm Heinbokel and Haruhito Azuma and Abdala El Khal and Stefan G. Tullius},
  journal={Transplant International},
Alloimmunity traditionally distinguishes short‐lived, rapid and nonspecific innate immune responses from adaptive immune responses that are characterized by a highly specific response initiated in a delayed fashion. Key players of innate immunity such as natural killer (NK) cells and macrophages present the first‐line defence of immunity. The concept of unspecific responses in innate immunity has recently been challenged. The discovery of pattern recognition receptors (PRRs) has demonstrated… Expand
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An Innate Response to Allogeneic Nonself Mediated by Monocytes1
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Adaptive Immune Features of Natural Killer Cells
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Natural killer cell memory
Evidence of NK cell–mediated, RAG-independent adaptive immunity is reviewed and candidate mechanisms for mammalian NK cell memory and antigen recognition are compared with other examples of R AG-independent pathways that generate antigen receptor diversity in non-mammalian species. Expand
KLRG+ invariant natural killer T cells are long-lived effectors
The presence of effector memory-like KLRG1+ (Killer cell lectin-like receptor subfamily G, member 1–positive) iNKT cells in the lung is shown and could result in a paradigm shift regarding the basis of newly developed extrathymic iN KT cells and could contribute to the future development of antitumor immunotherapy by uniquely energizing inKT cells. Expand
Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts
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Non-self recognition by monocytes initiates allograft rejection.
It is demonstrated that danger signals associated with dying cells are not sufficient to initiate alloimmunity, but that recognition of allogeneic non-self by the innate immune system is required. Expand
The Innate NK Cells, Allograft Rejection, and a Key Role for IL-151
It is found that NK cells at a resting state readily reject allogeneic cells, but not the skin allografts, and IL-15, when preconjugated to its high affinityIL-15Rα-chain, is remarkably potent in stimulating NK cells in vivo, and NK cells stimulated by IL- 15 express an activated phenotype and are surprisingly potent in mediating acute skinAllograft rejection in the absence of any adaptive immune cells. Expand
Critical role for the chemokine receptor CXCR 6 in NK cell – mediated antigen-specific memory of haptens and viruses
The textbook view of adaptive immunity is that it is mediated exclusively by T cells and B cells, which rely on nonhomologous recombination of variable, diversity and joining gene segments mediatedExpand
γδ T cells exhibit multifunctional and protective memory in intestinal tissues.
It is shown that a distinct subset of mucosal γδ T-cells mounts an immune response to oral Listeria monocytogenes infection and leads to the development of multifunctional memory T cells capable of simultaneously producing interferon-γ and interleukin-17A in the murine intestinal mucosa. Expand