Recalibration of the Limiting Antigen Avidity EIA to Determine Mean Duration of Recent Infection in Divergent HIV-1 Subtypes

@inproceedings{Duong2015RecalibrationOT,
  title={Recalibration of the Limiting Antigen Avidity EIA to Determine Mean Duration of Recent Infection in Divergent HIV-1 Subtypes},
  author={Yen Duong and Reshma Kassanjee and Alex Welte and Meade Morgan and Anindya De and Trudy L Dobbs and Erin K. Rottinghaus and John N Nkengasong and Marcel E. Curlin and Chonticha Kittinunvorakoon and Boonyos Raengsakulrach and Michael Martin and Kachit Choopanya and Suphak Vanichseni and Yan Jiang and Maofeng Qiu and Haiying Yu and Yan Hao and Neha Shah and L. Le and Andrea A. Kim and Tuan Anh Nguyen and William Kwabena Ampofo and Bharat S. Parekh},
  booktitle={PloS one},
  year={2015}
}
BACKGROUND Mean duration of recent infection (MDRI) and misclassification of long-term HIV-1 infections, as proportion false recent (PFR), are critical parameters for laboratory-based assays for estimating HIV-1 incidence. Recent review of the data by us and others indicated that MDRI of LAg-Avidity EIA estimated previously required recalibration. We present here results of recalibration efforts using >250 seroconversion panels and multiple statistical methods to ensure accuracy and consensus… CONTINUE READING
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