Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse

@article{Orlando2013RecalibratingEE,
  title={Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse},
  author={Ludovic Orlando and Aur{\'e}lien Ginolhac and Guojie Zhang and Duane G. Froese and Anders Albrechtsen and Mathias Stiller and Mikkel Schubert and Enrico Cappellini and Bent Petersen and Ida Moltke and Philip L. F. Johnson and Matteo Fumagalli and Julia T. Vilstrup and Maanasa Raghavan and Thorfinn Sand Korneliussen and Anna-Sapfo Malaspinas and Josef Korbinian Vogt and Damian Szklarczyk and Christian D. Kelstrup and Jakob Vinther and Andrei Dolocan and Jesper Stenderup and Amhed Missael Vargas Velazquez and James Andrew Cahill and Morten Rasmussen and Xiaoli Wang and Jiumeng Min and Grant Zazula and Andaine Seguin-Orlando and Cecilie Mortensen and Kim Magnussen and Johnf . Thompson and Jacobo Weinstock and Kristian Murphy Gregersen and Knut H. R{\o}ed and V{\'e}ra Eisenmann and Carl-Johan Rubin and Donald C. Miller and Douglas F Antczak and Mads Frost Bertelsen and S{\o}ren Brunak and Khaled A. S. Al-Rasheid and Oliver A. Ryder and Leif Andersson and John Hine Mundy and Anders Krogh and M. Thomas P. Gilbert and Kurt H. Kj{\ae}r and Thomas Sicheritz-Pont{\'e}n and Lars Juhl Jensen and Jesper Velgaard Olsen and Michael Hofreiter and Rasmus Nielsen and Beth Shapiro and Jun Wang and Eske Willerslev},
  journal={Nature},
  year={2013},
  volume={499},
  pages={74-78}
}
The rich fossil record of equids has made them a model for evolutionary processes. Here we present a 1.12-times coverage draft genome from a horse bone recovered from permafrost dated to approximately 560–780 thousand years before present (kyr bp). Our data represent the oldest full genome sequence determined so far by almost an order of magnitude. For comparison, we sequenced the genome of a Late Pleistocene horse (43 kyr bp), and modern genomes of five domestic horse breeds (Equus ferus… 
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