RecQ helicases: lessons from model organisms

@article{Cobb2006RecQHL,
  title={RecQ helicases: lessons from model organisms},
  author={Jennifer A Cobb and Lotte Bjergbaek},
  journal={Nucleic Acids Research},
  year={2006},
  volume={34},
  pages={4106 - 4114}
}
RecQ DNA helicases function during DNA replication and are essential for the maintenance of genome stability. There is increasing evidence that spontaneous genomic instability occurs primarily during DNA replication, and that proteins involved in the S-phase checkpoint are a principal defence against such instability. Cells that lack functional RecQ helicases exhibit phenotypes consistent with an inability to fully resume replication fork progress after encountering DNA damage or fork arrest… CONTINUE READING