RecQ helicase triggers a binding mode change in the SSB–DNA complex to efficiently initiate DNA unwinding

@inproceedings{Mills2017RecQHT,
  title={RecQ helicase triggers a binding mode change in the SSB–DNA complex to efficiently initiate DNA unwinding},
  author={Maria Mills and G{\'a}bor M. Harami and Yeonee Seol and M{\'a}t{\'e} Gyimesi and M{\'a}t{\'e} Martina and Zolt{\'a}n J. Kov{\'a}cs and Mih{\'a}ly Kov{\'a}cs and Keir C Neuman},
  booktitle={Nucleic acids research},
  year={2017}
}
The single-stranded DNA binding protein (SSB) of Escherichia coli plays essential roles in maintaining genome integrity by sequestering ssDNA and mediating DNA processing pathways through interactions with DNA-processing enzymes. Despite its DNA-sequestering properties, SSB stimulates the DNA processing activities of some of its binding partners. One example is the genome maintenance protein RecQ helicase. Here, we determine the mechanistic details of the RecQ-SSB interaction using single… CONTINUE READING

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