RecBCD is required to complete chromosomal replication: Implications for double-strand break frequencies and repair mechanisms.

@article{Courcelle2015RecBCDIR,
  title={RecBCD is required to complete chromosomal replication: Implications for double-strand break frequencies and repair mechanisms.},
  author={Justin Courcelle and Brian M Wendel and Dena D Livingstone and Charmain Tan Courcelle},
  journal={DNA repair},
  year={2015},
  volume={32},
  pages={
          86-95
        }
}
Several aspects of the mechanism of homologous double-strand break repair remain unclear. Although intensive efforts have focused on how recombination reactions initiate, far less is known about the molecular events that follow. Based upon biochemical studies, current models propose that RecBCD processes double-strand ends and loads RecA to initiate recombinational repair. However, recent studies have shown that RecBCD plays a critical role in completing replication events on the chromosome… CONTINUE READING

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