RecA protein-dependent R-loop formation in vitro.

  title={RecA protein-dependent R-loop formation in vitro.},
  author={Makoto Kasahara and Jennifer A Clikeman and Diana Bates and Tokio Kogoma},
  journal={Genes & development},
  volume={14 3},
The RecA protein of Escherichia coli, which has crucial roles in homologous recombination, DNA damage repair, induction of the SOS response, and SOS mutagenesis, was found to catalyze assimilation of complementary RNA into a homologous region of a DNA duplex (R-loop). The reaction strictly requires a region of mismatch in the duplex, which may serve as a nucleation site for RecA protein polymerization. The optimum conditions for the assimilation reaction resemble those for the previously… CONTINUE READING

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