Rebuilding motor function of the spinal cord based on functional electrical stimulation

@article{Shen2016RebuildingMF,
  title={Rebuilding motor function of the spinal cord based on functional electrical stimulation},
  author={Xiao-Yan Shen and Wei Du and Wei Huang and Yi Chen},
  journal={Neural Regeneration Research},
  year={2016},
  volume={11},
  pages={1327 - 1332}
}
Rebuilding the damaged motor function caused by spinal cord injury is one of the most serious challenges in clinical neuroscience. The function of the neural pathway under the damaged sites can be rebuilt using functional electrical stimulation technology. In this study, the locations of motor function sites in the lumbosacral spinal cord were determined with functional electrical stimulation technology. A three-dimensional map of the lumbosacral spinal cord comprising the relationship between… 
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References

SHOWING 1-10 OF 36 REFERENCES
Intraspinal microstimulation for the recovery of function following spinal cord injury.
TLDR
A historical review of intraspinal microstimulation (ISMS) and thoughts on the clinical potential for ISMS with regard to implantation techniques, stability, and damage induced by mechanical and electrical factors are presented.
Spinal cord stimulation: therapeutic benefits and movement generation after spinal cord injury.
TLDR
Taken collectively, spinal cord stimulation holds substantial promise in restoring function after neural injury or disease.
Spinal cord stimulation for restoration of locomotion
  • V. Mushahwar, R. Saigal
  • Medicine
    Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology
  • 2002
TLDR
Results indicate that ISMS may be a viable neuroprosthetic approach for improving or restoring limb movements after spinal cord injury and may also be used in conjunction with other rehabilitation approaches such as regeneration, locomotor training and neuropharmacology to enhance the functional benefits after injury.
Combinatory Electrical and Pharmacological Neuroprosthetic Interfaces to Regain Motor Function After Spinal Cord Injury
TLDR
It is shown that chemical or electrical stimulations can engage specific elements of this spinal machinery, thus resulting in distinct patterns of locomotion in paralyzed spinal rats, providing a strong rationale for the development of neuroprosthetic chemotrode and electrode arrays that would enable a detailed and distributed access to the different elements of the spinal motor infrastructure.
Therapeutic intraspinal stimulation to generate activity and promote long-term recovery
TLDR
Cervical intraspinal microstimulation (ISMS) is focused on as a promising method of activating the spinal cord distal to an injury site, either to directly produce movements or more intriguingly to improve subsequent volitional control of the paretic extremities.
Intraspinal micro stimulation generates locomotor-like and feedback-controlled movements
TLDR
By stimulating through a few intraspinal microwires, near-normal bipedal locomotor-like stepping and feedback-controlled movements could be achieved.
Spatiotemporal activation of lumbosacral motoneurons in the locomotor step cycle.
TLDR
A dynamic model of the spatiotemporal activation of ensembles of alpha motoneurons (MNs) in the cat lumbosacral spinal cord during the locomotor step cycle is produced and the distribution of neuronal activity in the spinal cords during normal locomotion with descending control and sensory inputs intact has not been visualized before.
Functional Electrical Stimulation Control of Standing and Stepping After Spinal Cord Injury: A Review of Technical Characteristics
TLDR
Progress in the development of closed‐loop FES walking systems has been impeded by their lack of practicality, but this obstacle could be overcome via implanted systems, especially if using controllers based on deterministic rule sets derived from motion sensor feedback.
Selective activation of muscle groups in the feline hindlimb through electrical microstimulation of the ventral lumbo-sacral spinal cord.
  • V. Mushahwar, K. Horch
  • Biology, Medicine
    IEEE transactions on rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
  • 2000
TLDR
The spatial and functional segregation of motor pools manifested at the spinal cord level can have direct applications in the areas of functional electrical stimulation and motor control.
Proposed specifications for a lumbar spinal cord electrode array for control of lower extremities in paraplegia.
  • V. Mushahwar, K. Horch
  • Medicine
    IEEE transactions on rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
  • 1997
TLDR
Preliminary specifications are presented for an electrode array to be implanted in the human spinal cord for functional neuromuscular stimulation for control of lower extremity muscles in paralyzed individuals.
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