Rebuilding cancer metastasis in the mouse.

  title={Rebuilding cancer metastasis in the mouse.},
  author={Meera Saxena and Gerhard Christofori},
  journal={Molecular oncology},
  volume={7 2},
Most cancer deaths are due to the systemic dissemination of cancer cells and the formation of secondary tumors (metastasis) in distant organs. Recent years have brought impressive progress in metastasis research, yet we still lack sufficient insights into how cancer cells migrate out of primary tumors and invade into neighboring tissue, intravasate into the blood or the lymphatic circulation, survive in the blood stream, and target specific organs to initiate metastatic outgrowth. While a large… CONTINUE READING