Rebuilding Pluripotency from Primordial Germ Cells

  title={Rebuilding Pluripotency from Primordial Germ Cells},
  author={Harry G. Leitch and Jennifer Nichols and Peter Humphreys and Carla Mulas and Graziano Martello and Caroline LG Lee and Ken A Jones and M. Azim Surani and Austin G. Smith},
  booktitle={Stem cell reports},
Mammalian primordial germ cells (PGCs) are unipotent progenitors of the gametes. Nonetheless, they can give rise directly to pluripotent stem cells in vitro or during teratocarcinogenesis. This conversion is inconsistent, however, and has been difficult to study. Here, we delineate requirements for efficient resetting of pluripotency in culture. We demonstrate that in defined conditions, routinely 20% of PGCs become EG cells. Conversion can occur from the earliest specified PGCs. The entire… CONTINUE READING
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