Rebound insomnia after only brief and intermittent use of rapidly eliminated benzodiazepines

@article{Kales1991ReboundIA,
  title={Rebound insomnia after only brief and intermittent use of rapidly eliminated benzodiazepines},
  author={A. Kales and R. Manfredi and A. Vgontzas and E. Bixler and A. Vela-Bueno and E. Fee},
  journal={Clinical Pharmacology & Therapeutics},
  year={1991},
  volume={49}
}
In three parallel groups, brief and intermittent administration and withdrawal of triazolam, 0.5 mg, temazepam, 30 mg, and placebo were assessed in a 12‐night sleep laboratory study of 18 subjects with insomnia. With this intermittent schedule both drugs improved sleep, with about a one‐third reduction in total wake time; this reduction was significant for temazepam but not for triazolam. Even though the periods of drug administration were quite brief, withdrawal of triazolam consistently… Expand
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