Rebound insomnia: a new clinical syndrome.

@article{Kales1978ReboundIA,
  title={Rebound insomnia: a new clinical syndrome.},
  author={Anthony Kales and Martin B. Scharf and Jennifer Kales},
  journal={Science},
  year={1978},
  volume={201 4360},
  pages={
          1039-41
        }
}
Rebound insomnia followed the withdrawal of three benzodiazepine hypnotic drugs, each of which had been administered in a single nightly dose for only short-term periods. The intense worsening of sleep is attributed to the short duration of the action of these drugs. A hypothesis involving benzodiazepine receptors in the brain is proposed in which there is a delay or lag in replacement of endogenous benzodiazepine-like molecules after the abrupt withdrawal of exogenous drugs. 
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Benzodiazepines: a review of research results, 1980.

NIDA research monograph • 1980
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