Rebamipide suppresses TLR-TBK1 signaling pathway resulting in regulating IRF3/7 and IFN-α/β reduction

@inproceedings{Ogasawara2011RebamipideST,
  title={Rebamipide suppresses TLR-TBK1 signaling pathway resulting in regulating IRF3/7 and IFN-α/β reduction},
  author={Naotaka Ogasawara and Makoto Sasaki and Yukimi Itoh and Kentaro Tokudome and Yoshihiro Kondo and Yoshitsugi Ito and Satoshi Tanida and Takeshi Kamiya and Hiromi Kataoka and Takashi Joh and Kunio Kasugai},
  booktitle={Journal of clinical biochemistry and nutrition},
  year={2011}
}
TANK-binding kinase 1 (TBK1) regulates the interferon regulatory factor (IRF) 3 and IRF7 activation pathways by double strand RNA (dsRNA) via Toll-like receptor (TLR) 3 and by lipopolysaccharide (LPS) via TLR4. Rebamipide is useful for treating inflammatory bowel disease (IBD). Although IBD is associated with nuclear factor-κB (NF-κB), any association with the TBK1-IRF pathway remains unknown. How rebamipide affects the TBK1-IRF pathway is also unclear. We analyzed the relationship between IBD… CONTINUE READING

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