Rebamipide ameliorates atherosclerosis by controlling lipid metabolism and inflammation

Abstract

RESULTS The oral administration of rebamipide decreased plaque formation in atherosclerotic lesions as well as the markers of metabolic disorder in ApoE-deficient mice with atherosclerosis. Pro-inflammatory cytokines were also suppressed by rebamapide. In addition, the population of Th17 was decreased, whereas Treg was increased in the spleen of rebamipide-treated ApoE deficient mice. Rebamipide also ameliorated the severity of obese arthritis and has the capability to reduce the development of atherosclerosis by controlling the balance between Th17 and Treg cells. Thus, rebamipide could be a therapeutic agent to improve the progression of inflammation in metabolic diseases.

DOI: 10.1371/journal.pone.0171674

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Cite this paper

@inproceedings{Jhun2017RebamipideAA, title={Rebamipide ameliorates atherosclerosis by controlling lipid metabolism and inflammation}, author={JooYeon Jhun and Jeong-Eun Kwon and Se-Young Kim and Jeong-Hee Jeong and Hyun Sik Na and Eun-Kyung Kim and Seung hoon Lee and Kyungah Jung and Jun-Ki Min and Mi-la Cho}, booktitle={PloS one}, year={2017} }