Rebamipide Enema is Effective for Treatment of Experimental Dextran Sulfate Sodium Induced Colitis in Rats

@article{TakakoNakashima2005RebamipideEI,
  title={Rebamipide Enema is Effective for Treatment of Experimental Dextran Sulfate Sodium Induced Colitis in Rats},
  author={BS TakakoNakashima and MS TakashiMaeda and Hisashi Nagamoto and BS TakeshiKumakura and Masaaki Takai DVM and PhD Toyoki Mori DVM},
  journal={Digestive Diseases and Sciences},
  year={2005},
  volume={50},
  pages={S124-S131}
}
We investigated therapeutic efficacy of rebamipide using dextran sulfate sodium (DSS) induced colitis model in rats. Three percent DSS solution was given to rats for 9 days. After that, we evaluated the drug efficacy on colitis sustained with continuous drinking of 1% DSS. Twice-daily treatment with 0.3% or 1% rebamipide for 14 days significantly ameliorated the stool abnormality in the colitis model, preferentially suppressed hematochezia. The colonic mucosal lesion, determined by Alcian blue… CONTINUE READING
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