Rebamipide Activates Genes Encoding Angiogenic Growth Factors and Cox2 and Stimulates Angiogenesis: A Key to Its Ulcer Healing Action?

@article{Tarnawski2004RebamipideAG,
  title={Rebamipide Activates Genes Encoding Angiogenic Growth Factors and Cox2 and Stimulates Angiogenesis: A Key to Its Ulcer Healing Action?},
  author={Andrzej S. Tarnawski and John Chai and Rama Pai and S K Chiou},
  journal={Digestive Diseases and Sciences},
  year={2004},
  volume={49},
  pages={202-209}
}
Clinical and experimental data indicate that rebamipide accelerates ulcer healing, improves scar quality, and prevents ulcer recurrence. However, the mechanisms responsible for these rebamipides' actions are not fully elucidated. We studied, using gene expression microarray analysis, which of the ulcer healing genes are activated by rebamipide treatment. Normal rat gastric epithelial cells (RGM1) were treated with either vehicle or rebamipide. Gene expression was determined using Affymetrix rat… 
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