Reassortment between seasonal H1N1 and pandemic (H1N1) 2009 influenza viruses is restricted by limited compatibility among polymerase subunits.

@article{Octaviani2011ReassortmentBS,
  title={Reassortment between seasonal H1N1 and pandemic (H1N1) 2009 influenza viruses is restricted by limited compatibility among polymerase subunits.},
  author={C{\'a}ssio Pontes Octaviani and Hideo Goto and Yoshihiro Kawaoka},
  journal={Journal of virology},
  year={2011},
  volume={85 16},
  pages={8449-52}
}
Reassortment is important for influenza virus evolution and the generation of novel viruses with pandemic potential; however, the factors influencing reassortment are still poorly understood. Here, using reverse genetics and a replicon assay, we demonstrated that a mixed polymerase complex containing a pandemic (H1N1) 2009 influenza virus PB2 on a seasonal H1N1 virus background has reduced polymerase activity, leading to impaired virus viability. Adaptation of viruses containing the mixed… CONTINUE READING

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