Reassortant analysis of guinea pig virulence of pichinde virus variants.

@article{Zhang2001ReassortantAO,
  title={Reassortant analysis of guinea pig virulence of pichinde virus variants.},
  author={Ling Zhang and Kathleen A Marriott and Delsworth G. Harnish and Judy F Aronson},
  journal={Virology},
  year={2001},
  volume={290 1},
  pages={30-8}
}
The new world arenavirus Pichinde (PIC) is the basis of an accepted small animal model for human Lassa fever. PIC (Munchique strain) variant P2 is attenuated in guinea pigs, whereas variant P18 is extremely virulent. Previous sequence analysis of the S segments of these two viruses indicated a small number of possible virulence markers in the glycoprotein precursor (GPC) and nucleoprotein (NP) genes. In order to determine the role of these S segment genes in guinea pig virulence in this system… CONTINUE READING