Reassociation of microvillar core proteins: making a microvillar core in vitro

@article{Coluccio1989ReassociationOM,
  title={Reassociation of microvillar core proteins: making a microvillar core in vitro},
  author={Lynne M. Coluccio and Anthony Bretscher},
  journal={The Journal of Cell Biology},
  year={1989},
  volume={108},
  pages={495 - 502}
}
Intestinal epithelia have a brush border membrane of numerous microvilli each comprised of a cross-linked core bundle of 15-20 actin filaments attached to the surrounding membrane by lateral cross-bridges; the cross-bridges are tilted with respect to the core bundle. Isolated microvillar cores contain actin (42 kD) and three other major proteins: fimbrin (68 kD), villin (95 kD), and the 110K-calmodulin complex. The addition of ATP to detergent-treated isolated microvillar cores has previously… CONTINUE READING

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