Reassessment of faecal x - 1 - antitrypsin excretion for use as screening test for intestinal protein loss

Abstract

or hepatic disease were compared. The reference range was derived from measurements in 20 controls without gastrointestinal disease. Alpha-l-antitrypsin excretion was increased in patients with excessive 5"Cr-albumin loss, and correlations were found between a-1-antitrypsin clearance and 51Cr-albumin excretion. Because of the considerable overlap of faecal a-l-antitrypsin excretion between controls and patients, sensitivity and specificity of the test were only 58% and 80%, respectively. This poor reliability could not be explained by sampling error or temporal variations in a-l-antitrypsin excretion. These results show that although faecal a-l-antitrypsin excretion correlates with 5"Cr-albumin excretion when whole groups of patients are studied, its poor sensitivity makes it an unreliable measure of enteric protein loss.

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Cite this paper

@inproceedings{Quigley2005ReassessmentOF, title={Reassessment of faecal x - 1 - antitrypsin excretion for use as screening test for intestinal protein loss}, author={Eamonn M M Quigley and I N Ross and Mansel R Haeney}, year={2005} }