Corpus ID: 53052843

Reassessing the Drug Potential of Industrial Hemp

  title={Reassessing the Drug Potential of Industrial Hemp},
  author={F. Grotenhermen and G. Leson},
4 Citations

Figures, Tables, and Topics from this paper

Systematics and Botanical Characteristics of Industrial Hemp Cannabis Sativa L
The systematic affiliation of Cannabis has been controversial for many years. Without a doubt, today we know that they belong to the order Rosales, family Cannabaceae, genus Cannabis, species – C. ...
Contribution of Polish agrotechnical studies on Cannabis sativa L. to the global industrial hemp cultivation and processing economy
Summary Industrial hemp (Cannabis sativa L.) attracts increasing interest of growers, in relation to both industrial and medical purposes. Construction is the most promising area of the economy forExpand
Cannabis use: a perspective in relation to the proposed UK drug-driving legislation.
Determining minimum blood THC concentrations at which a driver becomes sufficiently impaired to be unable to safely drive a vehicle is of particular concern given the increasing medicinal use of the drug. Expand
Driving under the Influence of Marijuana


Discriminative stimulus and subjective effects of smoked marijuana in humans
The discriminative stimulus (DS) effects of smoked marijuana were studied by training marijuana smokers to discriminate between the effects of marijuana containing 2.7% △9-THC (M) and marijuana containing 0.0% ▵9- THC (P), and this experimental paradigm could be used to determine whether the DS effects of smoking marijuana would generalize to those of other psychoactive drugs. Expand
Relationship between plasma delta-9-tetrahydrocannabinol concentration and pharmacologic effects in man
It is suggested that plasma THC concentration is a poor predictor of simultaneously occurring physiological and psychological pharmacologic effects. Expand
Marijuana smoking: effects of varying puff volume and breathhold duration.
The utility of the controlled smoking technology is confirmed, the notion that cumulative puff volume systematically influences biological exposure and subjective effects is supported, but the common belief that prolonged breathholding of marijuana smoke enhances classical subjective effects associated with its reinforcing value in humans is cast doubt. Expand
Blood cannabinoids. I. Absorption of THC and formation of 11-OH-THC and THCCOOH during and after smoking marijuana.
This study provides the first complete pharmacokinetic profile of the absorption of THC and appearance of metabolites during marijuana smoking, which has implications for understanding the mechanisms underlying the performance-impairing effects of marijuana, as well as for aiding forensic interpretation of cannabinoid blood levels. Expand
Plasma delta‐9‐tetrahydrocannabinol concentrations and clinical effects after oral and intravenous administration and smoking
After oral THC, the onset of clinical effects was much slower and lasted longer, but effects occurred at much lower plasma concentrations than after the other two methods of administration, suggesting that brain concentrations were increasing as plasma concentrations decreased. Expand
Influence of cannabidiol on delta‐9‐tetrahydrocannabinol effects
Experiments investigating the possible interaction of tetrahydrocannabinol (THC) and cannabidiol (CBD), two major components of marihuana, were conducted under controlled laboratory conditions in aExpand
Dose‐response analysis of the efJects of tetrahydrocannabinol in man
It was found that motor and mental performance as well as stability of stance deteriorated in a linearly dose‐dependent fashion. Expand
Marihuana-induced "high": influence of expectation, setting and previous drug experience.
Concentration-effect relationship of delta-9-tetrahydrocannabiol and prediction of psychotropic effects after smoking marijuana.
Simulation of the effect-time course after repeated smoking of marijuana in different intervals and for different dose strengths showed that dose and dosing interval are determinants of the duration of the psychotropic effects of THC. Expand
Metabolic studies of delta-9-tetrahydrocannabinol in cancer patients.
The metabolism of oral delta-9-tetrahydrocannabinol (THC) was studied in nine patients with gastrointestinal neoplasms receiving chemotherapy regimens containing 5-FU and semustine, finding no correlation between antiemetic effect or cannabinoid toxicity and plasma levels of the three metabolites could be made. Expand